Ho Leung Ng - Founder, Rise Bio

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Network Power<100 people

Roles

🔥50%

Startup Founder

💸50%

Marketing

✨50%

Business Owner

Geos

🇩🇪25%

Germany

🇮🇳25%

India

🇷🇴25%

Romania

Work Background

FreelanceConsultant

Jan. 2023Consultant in AI/computational drug discovery, structural biology

ConfometRxSr. Scientist

Jan. 2009 - Dec. 2011Santa Clara, CAG-protein coupled receptors (GPCRs) are the largest protein family of drug targets. Project responsibilities include recombinant expression, purification on the milligram scale, characterization, crystallization, and solving crystal structures of GPCRs. Established the crystallography lab at Confometrx. Part of team that crystallized and solved the novel structure of a GPCR. Worked directly under Nobel laureate Brian Kobilka.

AtomwisePrincipal Scientist

Apr. 2022 - Dec. 2022San Francisco, California, United StatesAI and computational drug discovery. Generative AI methods, lead optimization, virtual screening

Kansas State UniversityAssociate Professor of Biochemistry & Molecular Biophysics

Jan. 2017 - Dec. 2022Manhattan, KSCurrently volunteer adjunct status. Research is in AI drug discovery for cancer, immunology, and infectious disease. Previous research program was in computational structural biology/chemistry and protein crystallography, with a focus on machine learning, structure-based drug design, molecular dynamics, virtual screening, cancer, immunology, malaria, COVID19. Projects included RORgamma, SHP2, EZH2, drug resistant estrogen receptor, aromatase, fluorescent proteins, applications of machine learning to chemistry and drug discovery, identification of druggable sites on proteins, malarial kinases, GPCRs. Founder of OSC19, an open source drug discovery consortium for COVID-19. Anti-aging drug discovery Biophysical interests include developing methods for analyzing hydrogen atoms in x-ray and neutron crystallography data, super-resolution image processing of microscopy images, and biosensor proteins. We have also discovered potent RORgamma antagonists, aromatase inhibitors, an SHP2 inhibitor, and an EZH2 inhibitor. Taught advanced biochemistry, biochemistry for non-majors, medical biochemistry, molecular biophysics, general chemistry.

University of Hawaii at Manoa, University of Hawaii Cancer CenterAssistant Professor of Chemistry

Jul. 2011 - Jul. 2017Honolulu, HINSF CAREER Awardee for research on locating hydrogen atoms in X-ray and neutron crystal structures. Taught general chemistry, biophysical chemistry, research ethics, structural biology, and biochemistry. University teaching award nominee. Directed the largest lab on campus, with 25 students. Champion for student diversity.

UC BerkeleyAssociate Specialist

Jan. 2007 - Dec. 2009Protein crystallography, biochemistry, biophysics, computational biology. Solved crystal structure of red fluorescent protein engineered for in vivo mammalian imaging, elucidating red shift mechanism, in collaboration with Nobel laureate Roger Tsien. Solved crystal structure and proposed solvent/ion transport mechanism for the iron storage protein ferritin. Supervised undergraduate and PhD students.

UC BerkeleyPostdoctoral fellow

Jan. 2001 - Dec. 2007With Prof. Tom Alber. NIH Postdoctoral fellowship. Protein crystallography, biochemistry, biophysics, computational biology. Solved crystal structures of 2 protein kinases and 2 phosphatases involved in tuberculosis pathology. Crystallized the 400 kD yeast septin cytoskeletal protein complex. Developed computational method for characterizing low occupancy protein conformations in x-ray crystallography electron density maps. Supervised undergraduate and PhD students.

UCLAPhD student researcher

Jan. 1994 - Dec. 2001MD/PhD student researcher with National Academy members Profs. David Eisenberg and Richard Dickerson. NIH MSTP graduate fellowship. Solved the crystal structure of DNA with DNA binding drugs. Solved the first crystal structure of DNA in an intermediate conformation between A- and B-DNA, published in PNAS. Codeveloped an algorithm for predicting protein-protein interactions based on homologous gene fusions, published in Science with 2000+ citations.