A*STAR - Agency for Science, Technology and ResearchResearcher Phd Candidate
Nov. 2019 - May. 2022South West, SingaporePhD Project: Intensive focus on embryonic and placental development during human pregnancy. The first part of the project in Amsterdam was based on human model systems (cell lines, placental explants) aiming to unravel the underlying mechanisms of placentation and its key molecular players. The second part of the project that is being completed in Singapore is involving animal model systems (mice, zebrafish) and mouse and human Embryonic Stem Cells (ESCs) models that helped us study the translational inhibition of a crucial peptide for placentation and development, Elabela. By simulating situations leading to embryonic events such as identical twinning, and dysfunctional placentation causing pre-eclampsia and intra-uterine growth restriction, we aim to provide key insights into the origins of these events.