Bachisio Ziccheddu

Computational Biologist @University of Miami - Sylvester Comprehensive Cancer Center

ITResearcherMedicalEducationScientistMedical ResearcherData Analyst

I am a passionate and dedicated computational biologist specializing in hematological cancers, with a focus on leveraging genomic data to understand disease mechanisms and resistance to therapies. My career began in molecular biology during internships in Italy. However, my interests soon shifted to computational biology, driven by a growing fascination with genomics and bioinformatics. With a master's degree in genomic statistics and extensive experience working with leading research institutions such as the IRCCS Istituto Nazionale dei Tumori, University of Turin and the Sylvester Comprehensive Cancer Center at the University of Miami, I have honed my expertise in analyzing large-scale genomic datasets. My work spans multiple myeloma and lymphoma, where I focus on resistance mechanisms to advanced therapies, including CAR-T cell therapy and monoclonal antibodies. My research integrates whole genome sequencing (WGS), RNA-sequencing, single-cell transcriptomics, and flow cytometry to explore the intricate relationship between tumor biology and the immune system. These efforts have led to novel insights into disease progression, personalized medicine, and the development of machine learning models for clinical outcome predictions.

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Work Background

Sr. Research Analyst

University of Miami, Miller School of MedicineSr. Research Analyst

Jan. 2021Miami, Florida, Stati Uniti d'America

Visiting Research Scientist

IEO Istituto Europeo di OncologiaVisiting Research Scientist

Nov. 2019 - Jan. 2021MilanoAnalysis of NGS data from WGS of patients with acute myeloid leukemia

Bioinformatician

Università degli Studi di Torino - Dipartimento di Biotecnologie Molecolari e Scienza della SaluteBioinformatician

Mar. 2019 - Jan. 2021Torino, ItaliaGenomic and phenotypic determinants of resistance to immunotherapies in Multiple Myeloma

Visiting Research Scientist

IRCCS Istituto Nazionale dei Tumori Foundation, Milan, ItalyVisiting Research Scientist

Mar. 2019 - Jan. 2021Milano, ItaliaGenomic and phenotypic determinants of resistance to immunotherapies in Multiple Myeloma

Bioinformatician

IRCCS Istituto Nazionale dei Tumori Foundation, Milan, ItalyBioinformatician

Mar. 2018 - Mar. 2019Milano, Italia“Functional genomic and transcriptomic analysis of drug-resistant myeloma”.

Internship

AGRIS Sardegna - Genetica e Biotecnologie -Internship

Oct. 2016 - Mar. 2018Development of genomic data to identify regions associated with resistance to some infectious and parasitic diseases in sheep and identification of causative mutations or polymorphisms linked, which could be used in breeding programs. Activity: Genome-wide association studies (GWAS), genetic family structure and data imputation Acquired skills: R programming language and R-Bioconductor Merlin Plink Basic principle of Fortran Basic principle of Bash (Unix shell) Bioinformatic Tools Biological Database (NCBI, EMBL-EBI, Gene Onthology)

Internship Student

University of SassariInternship Student

Sep. 2014 - Apr. 2015Implementation of biomolecular diagnostic methods into assessment of the sheep, goats and cattle health state in relation to economic high impact pathology. Activity: Identification of microorganism (Mycoplasma agalactiae, Jaagsiekte sheep retrovirus (virus JSRV) e Mycobacterium avium subsp. paratuberculosis) in the sheep milk. Acquired skills: Bacterial culture isolation Acid Nucleic extraction PCR e RT-PCR Agarose gel electrophoresis Real-time PCR

Internship Student

University of SassariInternship Student

Mar. 2012 - Oct. 2012Study of the intra and inter-species variability of artichoke "Spinoso Sardo", with the microsatellite (SSR). Acquired skills: DNA extraction PCR (Polymerase Chain Reaction) Polyacrylamide gel electrophoresis

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Genomic Data Analyses Expertise

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