Nicola Powles -glover

Toxicologist @Regulatory Science Associates (RSA)

United Kingdom🧮 EducationTutorScientist🧨 Consulting

Nicola Powles-Glover is a highly experienced toxicologist/reproductive toxicologist who was working at AstraZeneca. Her role involved evaluating the safety and potential toxic effects/developmental and reproductive effects of new pharmaceutical compounds. She was a critical part of the drug development process, helping to ensure that all new drugs meet stringent safety standards. Nicola's expertise in toxicology, reproductive and developmental toxicology, paediatric toxicology, human and environmental health, combined with her strong scientific background, made her an invaluable asset to the research and development team.Nicola also has strong collaborations with HESI and the European Teratology Society (ETS) where she was previously the president of the society. Nicola has been the guest editor for the Reproductive Toxicology Journal and is on the editorial committee. Nicola is a European Registered Toxicologist.

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Work Background

knoellSenior Scientist | Toxicologist | Environmental and Human Health

Dec. 2023Cardiff, Wales, United Kingdom · Remote

AstraZenecaReproductive and Paediatric Toxicologist

Jun. 2009 - Dec. 2023

MRCPost-doc

Jan. 2003 - Dec. 2009On completion of my PhD I remained in the field of molecular biology, genetics, developmental biology and stem cells. Post-doc positions focussed on a number of mouse mutants with different phenotypes. This combined experience encompasses embryology from conception to just prior to birth using techniques such as all molecular biology, imaging, immunohistochemistry, ISH, gene manipulation, transgenics, cell culture, ES cell technologies and of course developmental biology. Because of my active involvement in promoting science through lecturing to gifted and talented students and working with schools; I was seconded to the position of Regional Communications Manager – South West for the MRC. I was a senior communication link between MRC Head Office, the CEO and Units/MRC grant holders in the South-West region.

MRCResearch Assistant/Part time PhD Student

Jan. 1996 - Dec. 2002At the Medical Research Council (MRC) Mammalian Genetics Unit, I worked as a RA/ managed molecular biology and ES cell laboratories for the unit and completed a PhD part-time (in 4 years - 2000 - 2003). My PhD focused on the genes involved in mouse inner ear development. Making/screening an otic vesicle library; culturing/manipulating embryonic stem cells for gene targeting, making and characterising transgenic mice.

GlaxoSmithKlineStudent

Jan. 1993 - Dec. 19961993 – 1994 - Glaxo Research and Development, Ware, Herts. Responsibilities - Sandwich Year Student for one year in the Genetic Toxicology Department conducting an investigation into the reliability of the Comet Assay (Single Cell Electrophoresis Assay) to give consistent significant results. This project formed a large proportion of a greater assessment of the assay in preparation of the assay to be used in routine batch testing of drugs to establish their effect on a single cell’s DNA within the testing regime in the Genetic Toxicology Department. This was carried out as part completion of a BSc (Hons) degree in Pharmacology and Toxicology. 1995 – 1996- F.O.R.C.E Cancer Centre, Royal Devon and Exeter Hospital, Exeter. Responsibilities - Conducted a project investigating the presence and variable lengths of telomeres in a number of different cell types in the blood. This work was a project in part completion for a MSc Degree from the University of Exeter. This work involved molecular biology and tissue culture techniques as well as some flow cytometry, tutoring an undergraduate tutorial group and demonstrating to undergraduate students.