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Work Background
SENOTHERAPEUTIX, Inc.Scientist
Jul. 2023Houston, Texas, United States
DELIVER Therapeutics, Inc.Scientist
Jul. 2023Houston, Texas, United States
The Ohio State UniversityResearch Assistant
Jan. 2019 - May. 2023Columbus, Ohio, United States
The Ohio State UniversityTeaching Assistant
Aug. 2018 - Dec. 2019Columbus, Ohio
AirBnB and VRBOHospitality Manager
Mar. 2018 - May. 2018Wilmington, North Carolina
University of North Carolina at WilmingtonGraduate Research Assistant
Aug. 2017 - May. 2018Wilmington, North Carolina AreaSYNTHESIS OF FUNCTIONALIZED β-AMINO ALCOHOLS AND β-AZIDO ALCOHOLS USING ORGANOCATALYSIS High demand for synthetic amino acids and amino alcohols in the medical and pharmaceutical industries calls for new synthetic methods, especially within organocatalysis. Enantioselective α-sulfamidation of aldehydes using sulfonyl azides is a relatively simple method to produce non-proteinogenic amino acids and amino alcohols using the commercially-available MacMillan catalyst, (2R,5R)-2-tert-butyl-3-methyl-5-benzyl-4-imidazolidinone. With a generalized synthesis previously developed, this study focused on evaluating the scope of aldehydes available for α-sulfamidation as well as oxidation and deprotection methods. Compounds containing electron-donating groups on the aromatic ring gave the best combination for yield and enantiomeric excess. Oxidation through Jones’s reagent and removal of the nitrobenzene sulfonyl protecting group with a weak base and thiophenol result in no loss in enantiomeric excess. Another method for producing amino acids and amino alcohols is through the α-azidation of α,β–epoxysulfones to yield α-azido aldehydes. An optimized, enantioselective procedure for α-azidation was developed along with an optimized phase-transfer catalyzed Darzens reaction for the synthesis of α,β–epoxysulfones. Both α-sulfamidation and α-azidation methods will provide precursors to chiral natural products or enable cascade reactions for the synthesis of heterocycles.
University of North Carolina at WilmingtonGraduate Teaching Assistant
Aug. 2015 - Aug. 2017University of North Carolina Wilmington Department of Chemistry and BiochemistryTeaching undergraduate chemistry labs including CHM 101 and CHM 211. Grading lab reports and proctoring exams.
UNC WilmingtonResearch Assistant
May. 2014 - May. 2015University of North Carolina Wilmington Department of Chemistry and BiochemistryTRAPPING CYCLOPENTADIENOL: APPLICATIONS TO THE SYNTHESIS OF KUCHINOENAMINE ANALOGS Kuchinoenamine is an alkaloid isolated from a marine sponge of the genus Hexadella in 2005 and was determined to have moderate antibacterial activity against Aeromonas hydrophila, a bacterium which infects fish, amphibians, and humans. Due to kuchinoenamine's limited availability in sponges and modest antibacterial activity, it is necessary to find ways to synthetically produce this compound and analogs if it is to be further evaluated and optimized as a medicinal compound. Cyclopentadienol forms from the decomposition of ferrocenium hexafluorophosphate and dimerizes to produce the crystalline tricyclic core of kuchinoenamine. This project evaluated the feasibility of trapping the cyclopentadienol with added external dienophiles. Maleic anhydride, N-benzylmaleimide, and 1,4-naphthoquinone, among others, were shown to be competent dienophiles, producing novel analogs of the kuchinoenamine tricyclic core in good-to-excellent yields after optimization. These analogs have been transferred to microbiologists at UNCW to be screened for antibiotic activity. The product formed using 1,4-naphthoquinone was determined to have antibacterial activity against Staphylococcus epidermidis, normal flora which can lead to nosocomial infections. Further reactions will be performed to systematically alter the structure of this compound in order to determine how changes in structure impact its antibacterial activity.
CVS HealthCertified Pharmacy Technician
May. 2013 - Oct. 20151712 Eastwood Road Wilmington, NCCollection, organization, and evaluation of patient information. Management of medication distribution and providing drug information and education to the patient or consumer. Preparing, dispensing, distributing, and administering medications under the direct supervision of the pharmacist. Complete understanding and appreciation for the use and side effects of prescription and nonprescription drugs used to treat common disease states. Demonstrate ethical conduct and maintain confidentiality of patient information.
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