Requests
0
3
8
0
Keep in touch with meI'm using Intch to connect with new people. Use this link to open chat with me via Intch app
Work Background
Thomas Jefferson UniversitySenior Research Investigator
Jan. 2023Philadelphia, Pennsylvania, United StatesLed group of biologists and clinicians in identifying ways to overcome drug resistance in diffuse large B cell lymphomas (Adams et al, Cancers 2024). - Generated and maintained multiple drug-resistant cell lines - Coordinated with multiple facilities to preform drug screens and RNA-sequencing - Collaborated with a biorepository to obtain fresh patient samples - Worked with bioinformaticians to identify top drug hits and changes in gene expression - Designed experiments for and managed graduate students, technicians, a Clinical Fellow, and a Research Associate - Performed multiple cell-based assays to monitor cell growth/survival and cell death - Data analysis using Microsoft Office, GraphPad Prism, and FlowJo - Manuscript preparation including writing, editing, and figure preparation Led cross-disciplinary team in a high-impact study (Adams et al, Cancer Discovery 2023) using innovative Proteolysis Targeting Chimera (PROTAC) technology to degrade MDM2 in triple negative breast cancer. - Collaborated with medicinal chemists to design and make a new MDM2 PROTAC - Established new methods/protocols in our lab to evaluate treatment responses in cell lines, patient-derived 3D/spheroid cultures, and patient-derived explant cultures from fresh tumor biopsies - Worked with a board-certified breast cancer pathologist to evaluate treatment responses - Completed multiple in vivo (mouse) studies, starting from initial toxicity testing and subsequent xenograft tumor models - Performed many cell-based assays to measure cell growth/survival and cell death - Worked side-by-side with bioinformaticians to determine changes in gene expression through RNA-seq - Obtained mechanistic insights using methods to evaluate changes in RNA, DNA, and protein - Data analysis using Microsoft Office, GraphPad Prism, ImageJ, and FlowJo - Manuscript preparation, including writing, editing, and figure preparation
Thomas Jefferson UniversityResearch Associate
Jan. 2021 - Dec. 2022Philadelphia, Pennsylvania, United StatesWorked closely with a bioinformatician to validate newly identified long non-coding RNAs across multiple cancer types (Mitra, Adams, et al Cancer Research Communications 2023; Mitra, Adams, et al eLife 2022) - Performed diverse cell-based assays to measure cell growth and viability - Evaluated genome-wide changes in gene expression through RNA-seq - Designed and tested primers to validate sequencing results with qRT-PCR - Interpretation of ENCODE ChIP-seq data to identify transcription factor binding sites - Determined if changes in RNA were reflected at the protein level with Western blotting - Data analysis using Microsoft Office, GraphPad Prism, FlowJo - Manuscript preparation, including writing, editing, and figure preparation - Received independent grant funding through the Ovarian Cancer Research Alliance (OCRA) Provided technical expertise for internal and external collaborations - Mouse tissue harvesting/processing for immuno-phenotyping, RNA isolation and preparation for RNA-seq (Aging Cell, 2024) - Processed and treated fresh patient samples, performed mouse toxicity testing followed by xenograft mouse tumor study (Molecular Cancer Therapeutics, 2024) - Data analysis using Microsoft Office, GraphPad Prism, FlowJo - Manuscript preparation, including writing, editing, and figure preparation
Thomas Jefferson UniversityPostdoctoral Research Fellow
Jan. 2016 - Dec. 2020Philadelphia, Pennsylvania, United StatesLed high-impact studies showing importance of cell death protein BCL-W across multiple types of B cell lymphomas (Adams, et al Leukemia, 2019; Adams, et al Clinical Cancer Research, 2017; Adams, et al Journal of Clinical Investigation, 2017). - Identified new microRNA-mediated mechanism by which the MYC oncogene regulates expression of cell death proteins - Performed drug dose titration assays to identify possible new therapies - Designed and cloned DNA constructs to test microRNA binding through standard luciferase binding assays - Evaluated cell survival by performing several cell growth/proliferation and cell death assays - Worked with board-certified pathologists to identify antibodies to use for immuno-histochemistry (IHC) to evaluate protein expression in human patient samples - Collaborated with a patient sample biorepository to obtain fresh human patient samples - Performed multiple RNA, DNA, and protein-based assays to gain mechanistic insights - Primer design and validation/testing - Worked closely with a bioinformatician to evaluate genome-wide RNA expression of BCL-W in multiple types of B cell lymphoma - Completed B cell lymphoma mouse survival study - Responsible for generating and maintaining mouse colonies needed for these studies, including mouse husbandry, DNA extraction and subsequent PCR genotyping, and health monitoring - Data analysis using Microsoft Office, GraphPad Prism, FlowJo - Manuscript preparation, including writing, editing, and figure preparation Contributed to paradigm-shifting study that identified Mdm2 as being a necessary protein for tumor cell survival (Feeley, Adams, et al Cancer Research, 2017) - Provided technical expertise to perform xenograft mouse tumor studies - Evaluated changes in protein expression through Western blotting - Completed flow cytometry assays to monitor cell death - Data analysis and manuscript preparation including editing and figure preparation
Vanderbilt University Medical CenterPredoctoral Graduate Student
Aug. 2009 - Dec. 2015Nashville, Tennessee, United StatesDissertation title: “The contribution of miRNA biogenesis and Myc-regulated miRNA in apoptosis and tumorigenesis” - Led multiple projects that resulted in 5 first-author and 2 second-author publications (Adams & Eischen Cancer Research 2014, Adams & Eischen Cell Death & Differentiation 2016, Adams & Eischen Molecular & Cellular Oncology 2014)
- Secured my own funding with an F31 grant from the NIH/NCI Ruth L. Kirschstein National Research Service Award (NRSA) Pre-Doctoral Fellowship
- Received funding for research supplies through the Vanderbilt Institute for Clinical and Translational Research Pre-Doctoral Trainee Resource Award
- Received a competitive position on a NIH/NIGMS T32 training grant for my first 2 years of graduate school
Intch is a Professional Networking App for the Future of WorkSee more people like Clare on Intch
300k+ people
130+ countries
AI matching
Get Intch if you'd like to
424405 people
21
Education Consultant
15
Production manager/training Professor @ Daytona State College
33
Financial consultant @ Nedixprimecrypto.com
26316 people
17
Data Scientist
17
Circular Economy consultant @ Natu
16
Chief Operations Officer @ Professional Co-op Laboratory Services