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Work Background
Thomas Jefferson UniversitySenior Research Investigator
Jan. 2023Philadelphia, Pennsylvania, United StatesLed group of biologists and clinicians in identifying ways to overcome drug resistance in diffuse large B cell lymphomas (Adams et al, Cancers 2024). - Generated and maintained multiple drug-resistant cell lines - Coordinated with multiple facilities to preform drug screens and RNA-sequencing - Collaborated with a biorepository to obtain fresh patient samples - Worked with bioinformaticians to identify top drug hits and changes in gene expression - Designed experiments for and managed graduate students, technicians, a Clinical Fellow, and a Research Associate - Performed multiple cell-based assays to monitor cell growth/survival and cell death - Data analysis using Microsoft Office, GraphPad Prism, and FlowJo - Manuscript preparation including writing, editing, and figure preparation Led cross-disciplinary team in a high-impact study (Adams et al, Cancer Discovery 2023) using innovative Proteolysis Targeting Chimera (PROTAC) technology to degrade MDM2 in triple negative breast cancer. - Collaborated with medicinal chemists to design and make a new MDM2 PROTAC - Established new methods/protocols in our lab to evaluate treatment responses in cell lines, patient-derived 3D/spheroid cultures, and patient-derived explant cultures from fresh tumor biopsies - Worked with a board-certified breast cancer pathologist to evaluate treatment responses - Completed multiple in vivo (mouse) studies, starting from initial toxicity testing and subsequent xenograft tumor models - Performed many cell-based assays to measure cell growth/survival and cell death - Worked side-by-side with bioinformaticians to determine changes in gene expression through RNA-seq - Obtained mechanistic insights using methods to evaluate changes in RNA, DNA, and protein - Data analysis using Microsoft Office, GraphPad Prism, ImageJ, and FlowJo - Manuscript preparation, including writing, editing, and figure preparation
Thomas Jefferson UniversityResearch Associate
Jan. 2021 - Dec. 2022Philadelphia, Pennsylvania, United StatesWorked closely with a bioinformatician to validate newly identified long non-coding RNAs across multiple cancer types (Mitra, Adams, et al Cancer Research Communications 2023; Mitra, Adams, et al eLife 2022) - Performed diverse cell-based assays to measure cell growth and viability - Evaluated genome-wide changes in gene expression through RNA-seq - Designed and tested primers to validate sequencing results with qRT-PCR - Interpretation of ENCODE ChIP-seq data to identify transcription factor binding sites - Determined if changes in RNA were reflected at the protein level with Western blotting - Data analysis using Microsoft Office, GraphPad Prism, FlowJo - Manuscript preparation, including writing, editing, and figure preparation - Received independent grant funding through the Ovarian Cancer Research Alliance (OCRA) Provided technical expertise for internal and external collaborations - Mouse tissue harvesting/processing for immuno-phenotyping, RNA isolation and preparation for RNA-seq (Aging Cell, 2024) - Processed and treated fresh patient samples, performed mouse toxicity testing followed by xenograft mouse tumor study (Molecular Cancer Therapeutics, 2024) - Data analysis using Microsoft Office, GraphPad Prism, FlowJo - Manuscript preparation, including writing, editing, and figure preparation
Thomas Jefferson UniversityPostdoctoral Research Fellow
Jan. 2016 - Dec. 2020Philadelphia, Pennsylvania, United StatesLed high-impact studies showing importance of cell death protein BCL-W across multiple types of B cell lymphomas (Adams, et al Leukemia, 2019; Adams, et al Clinical Cancer Research, 2017; Adams, et al Journal of Clinical Investigation, 2017). - Identified new microRNA-mediated mechanism by which the MYC oncogene regulates expression of cell death proteins - Performed drug dose titration assays to identify possible new therapies - Designed and cloned DNA constructs to test microRNA binding through standard luciferase binding assays - Evaluated cell survival by performing several cell growth/proliferation and cell death assays - Worked with board-certified pathologists to identify antibodies to use for immuno-histochemistry (IHC) to evaluate protein expression in human patient samples - Collaborated with a patient sample biorepository to obtain fresh human patient samples - Performed multiple RNA, DNA, and protein-based assays to gain mechanistic insights - Primer design and validation/testing - Worked closely with a bioinformatician to evaluate genome-wide RNA expression of BCL-W in multiple types of B cell lymphoma - Completed B cell lymphoma mouse survival study - Responsible for generating and maintaining mouse colonies needed for these studies, including mouse husbandry, DNA extraction and subsequent PCR genotyping, and health monitoring - Data analysis using Microsoft Office, GraphPad Prism, FlowJo - Manuscript preparation, including writing, editing, and figure preparation Contributed to paradigm-shifting study that identified Mdm2 as being a necessary protein for tumor cell survival (Feeley, Adams, et al Cancer Research, 2017) - Provided technical expertise to perform xenograft mouse tumor studies - Evaluated changes in protein expression through Western blotting - Completed flow cytometry assays to monitor cell death - Data analysis and manuscript preparation including editing and figure preparation
Vanderbilt University Medical CenterPredoctoral Graduate Student
Aug. 2009 - Dec. 2015Nashville, Tennessee, United StatesDissertation title: “The contribution of miRNA biogenesis and Myc-regulated miRNA in apoptosis and tumorigenesis” - Led multiple projects that resulted in 5 first-author and 2 second-author publications (Adams & Eischen Cancer Research 2014, Adams & Eischen Cell Death & Differentiation 2016, Adams & Eischen Molecular & Cellular Oncology 2014)
- Secured my own funding with an F31 grant from the NIH/NCI Ruth L. Kirschstein National Research Service Award (NRSA) Pre-Doctoral Fellowship
- Received funding for research supplies through the Vanderbilt Institute for Clinical and Translational Research Pre-Doctoral Trainee Resource Award
- Received a competitive position on a NIH/NIGMS T32 training grant for my first 2 years of graduate school
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