McMaster UniversityPhD candidate
Sep. 2002 - Jun. 2009I did my PhD in Dr. Catherine Hayward's lab, studying a rare inherited bleeding disorder called Quebec Platelet Disorder, QPD. Using both biochemical and molecular methods, I determined that individuals with QPD harbor a mutation at the locus for the urokinase plasminogen activator (uPA) gene (PLAU) that results in overexpression of uPA, and accelerated clot lysis. Thus, I contributed to the understanding about why individuals with QPD have delayed-onset bleeding after trauma that is only treatable with fibrinolytic inhibitors. In addition, I contributed to the work that identified the exact mutation in QPD individuals- a duplication of the PLAU gene.